An enantioselective synthesis of carbafuranose sugars based on a linchpin carbacyclisation approach |
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| Authors: | Leo M.H. Leung Mark E. Light Vicky Gibson Bruno Linclau |
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| Affiliation: | 1. School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, UK;2. Carbosynth Ltd, 8&9 Old Station Business Park, Compton, Berkshire RG20 6NE, UK |
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| Abstract: | Enantiopure carbafuranose derivatives were synthesised via a linchpin carbacyclisation process starting from 1,4-bisepoxides. Both 2-deoxy and 2-deoxy-6-hydroxycarbafuranose derivatives were obtained, which were converted to suitably protected precursors for carbanucleoside synthesis. |
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