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Enantiopure β3-neopentylglycine: synthesis and resolution |
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| Authors: | Matthijs KJ ter Wiel Mirjam Arnold Sandra Peter Ingo Troltsch Stefan Merget Florian Glaser Michael Schwarm Harjinder S Bhatti Biju Kuriakose Suryakant S Pol Mohanasundaram Balamurugan Viral V Joshi |
| Institution: | 1. Evonik Degussa GmbH, R&D Exclusive Synthesis and Amino Acids, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang, Germany;2. AQura GmbH, Organic Analysis and Chromatography, Rodenbacher Chaussee 4, 63457 Hanau-Wolfgang, Germany;3. Evonik Degussa India Pvt. Ltd, Krislon House, Saki Vihar Road, Saki Naka, Mumbai 400072, India |
| Abstract: | A procedure has been developed for the large scale synthesis of enantiopure β3-neopentylglycine and its Cbz-protected derivative. The synthetic route developed in our laboratory features Cbz-protection of the racemic β-amino acid followed by resolution with l-norephedrine and provides the enantiomerically pure Cbz-β-neopentylglycine in good yield and excellent enantiopurity. No toxic or dangerous chemicals are used, allowing the scale-up of this procedure without major safety concerns. |
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