A short approach to the synthesis of the ritonavir and lopinavir core and its C-3 epimer via cross metathesis |
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Authors: | Errabelli Ramu B Venkateswara Rao |
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Institution: | Organic Division III, Indian Institute of Chemical Technology, Hyderabad 500007, India |
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Abstract: | A short synthesis of hydroxyethylene dipeptide isostere, a core unit of the HIV-protease inhibitors ritonavir and lopinavir, its C-3 epimer and C2 symmetric diamino diol is described. The crucial aspects of the synthesis are self-cross metathesis and exploitation of C2-symmetric of the metathesis product 8 to obtain the required skeleton. |
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