A chemoenzymatic asymmetric synthesis of methyl (6S,13R)-6,13-dihydroxytetradeca-(2E,4E,8E)-trienoate,a component of Mycosphaerella rubella |
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Authors: | Anubha Sharma Sunita Gamre Subrata Chattopadhyay |
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Institution: | Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India |
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Abstract: | The first asymmetric synthesis of (6S,13R)-6,13-dihydroxytetradeca-(2E,4E,8E)-trienoate has been developed. The key steps of the synthesis were the use of an efficient lipase-catalyzed acylation, a chiral template-driven enantiocontrolled allylation for introducing the stereogenic centers, and a cross-metathesis for controlling the C-8 olefin geometry. |
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