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Electrochemical methods in understanding the redox processes of drugs and biomolecules and their sensing
Authors:Sudipa Manna  Abhishek Sharma  AK Satpati
Institution:1. Analytical Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400085, India;2. Homi Bhabha National Institute (HBNI), Anushaktinagar, Mumbai 400094, India
Abstract:Progression of the biochemical information of drugs and its interaction with biological substances require efficient methodologies suitable for generating information without incurring any significant damage to the analytes. Electrochemical methods provide useful information and compatible to the biological environments, without any significant alterations in the analyte, the methods are capable in onsite applications. Present review discusses about the application of the electrochemical techniques in evaluating the mechanism of interaction of drugs with the biomaterials like proteins, lipids, and DNA. The redox process leads to the determination of the drugs and biomolecules through the development of modified electrodes. The modified ultra-microelectrodes (UMEs) or nano electrodes are useful in sensing at the extracellular level of single cells. The electrochemical collision using UMEs provides information about the single molecular level. Present article discusses a brief review of some of the drug and biomolecule interactions using macro and also UMEs.
Keywords:Electrochemistry  Drugs  Biomolecule  Lipid membrane  Ultra-microelectrode  Cellular level detection  Electrochemical collision
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