Bioelectrochemistry for various facets of tau protein biochemistry |
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Authors: | Tyra Lewis Anasofia Vargas Sanela Martic |
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Institution: | Department of Forensic Science, Environmental and Life Sciences Program, Trent University, K9L 0G2, Canada |
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Abstract: | Tau protein undergoes complex biochemical processes involved in normal and diseased cellular functions; specifically, tau pathology has been linked to neurodegeneration. At the heart of tau biochemistry are three pillars: microtubules, phosphorylation, and aggregation. However, these three processes are also regulated through other biomolecules in the biological setting, such as metal ions and small and larger ligands, including proteins and nucleic acids. This review describes the latest electrochemical approaches toward greater understanding of tau biochemistry, early disease diagnosis, and drug inhibitor screening. |
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Keywords: | Neurodegenerative disease Tau protein Aggregation Phosphorylation Metal ions Impedance Voltammetry |
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