Highly sensitive analysis strategies of microRNAs based on electrochemiluminescence |
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| Authors: | Yanhua Chen Zhifeng Ding |
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| Institution: | 1. College of Chemistry, Jilin University, Changchun, Jilin 130012, China;2. Department of Chemistry, The University of Western Ontario, London, Ontario N6A 5B7, Canada |
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| Abstract: | The ultrasensitive detection of microRNAs (miRNAs) is currently pursued for the diagnosis of diseases. Due to its outstanding sensitivity, electrochemiluminescence (ECL) is expected to be very effective toward the above goal. In this short review, bioanalytical strategies currently employed in ECL detections of miRNAs are summarized. ECL sensors based on electrochemiluminescent resonance energy transfer (ERET), hybridization chain reaction (HCR), strand displacement reaction (SDR), and other strategies, have an extremely low detection limit of 10?18 M miRNA. In particular, the establishment of miniaturized ECL sensors has shown great potential for point-of-need testing of diseases. |
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| Keywords: | microRNA (miRNA) Electrochemiluminescence (ECL) ECL sensors Point-of-need detection Medical diagnosis |
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