Amine-catalyzed coupling of aldehydes and ketenes derived from Fischer carbene complexes: formation of beta-lactones and enol ethers |
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| Authors: | Merlic Craig A Doroh Brandon C |
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| Institution: | Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles Young Drive, Los Angeles, California 90095-1569, USA. merlic@chem.ucla.edu |
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| Abstract: | Aldehydes react with ketenes generated from photolysis of Fischer chromium carbene complexes to generate either beta-lactones or enol ethers resulting from decarboxylation of beta-lactones. The reaction is catalyzed by tertiary amines and can occur with diastereoselectivity greater than 20:1 with DMAP as the catalyst. |
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