Cu2+ -mediated assembly of the minor groove binders on the DNA template with sequence selectivity |
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| Authors: | Tanada Mikimasa Tsujita Saori Kataoka Tomonobu Sasaki Shigeki |
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| Institution: | Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. |
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| Abstract: | The ligands (Bpy-H, 5) have been designed to connect the Hoechst33258 skeleton for DNA binding and 2,2'-bipyridine for Cu(2+) complexation. It has been revealed that the new Hoechst ligand long Bpy-H (5L) having a long linker exhibits Cu(2+)-mediated assembly on the DNA template having two A(3)T(3) sites in a selective manner depending on the length of the linker of the ligand as well as on the distance between the two A(3)T(3) sites of DNA. reaction: see text] |
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