Determination of captopril in patient human urine using ferrocenemonocarboxylic acid modified carbon nanotubes paste electrode |
| |
Authors: | Mohammad A Khalilzadeh Hassan Karimi-Maleh Azra Amiri Fathali Gholami Robabeh Motaghed mazhabi |
| |
Institution: | a Department of Chemistry, Islamic Azad University, Qaemshahr Branch, Iran;b Department of Chemistry, Islamic Azad University, Lahijan Branch, Iran |
| |
Abstract: | In this work, we describe an new strategy for electrochemical determination of captopril (CA) using ferrocenemonocarboxylic acid as a mediator and multi wall carbon nanotubes as sensors in aqueous solution at pH=7.0. The diffusion coefficient (D), and the kinetic parameters such as electron transfer coefficient, (α) and heterogeneous rate constant, (kh) for CA were also determined using electrochemical approaches. Under the optimized conditions, the electrocatalytic oxidation peak current of captopril showed two linear dynamic ranges with a detection limit of 0.3×10-6 mol L-1 captopril. The linear calibration ranges was 0.8 × 10-6 ─ 65 × 10-6 mol L-1 using cyclic voltammetry. Finally, this modified electrode was also examined as a selective, simple and precise new electrochemical sensor for the determination of captopril in real samples such as drug and patient human urine. |
| |
Keywords: | Captopril determination Carbon nanotubes paste electrode Ferrocenemonocarboxylic acid Electrocatalytic Voltammetry |
本文献已被 CNKI 万方数据 ScienceDirect 等数据库收录! |
| 点击此处可从《中国化学快报》浏览原始摘要信息 |
| 点击此处可从《中国化学快报》下载免费的PDF全文 |
|