On the supramolecular mechanism of cell-cell commutation |
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Authors: | S. V. Stovbun A. I. Mikhailov A. A. Skoblin E. E. Bragina M. A. Gomberg |
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Affiliation: | 1.Semenov Institute of Chemical Physics,Russian Academy of Sciences,Moscow,Russia;2.Belozersky Institute of Physicochemical Biology,Moscow State University,Moscow,Russia;3.Moscow State Medical Stomatological University,Moscow,Russia |
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Abstract: | Processes of cell commutation via anisometric supramolecular structures (strings) are considered in vitro and using physicochemical models of lipids and trifluoroacetylated amino alcohols. The biological effectiveness of commutation via strings is demonstrated to be higher compared to the diffusion mechanism of transfer of biologically active molecules over distances between objects typical of populations of microorganisms. A kinetic model of strings is developed, and the rate of signal transmission in such systems is estimated. It is shown that the condition of the chirality of lipids forming the biomembranes of cells follows from the experimentally observed cell commutation by means of supramolecular anisometric structures. |
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