| 采用超疏水微柱阵列模板法制备多糖凝胶微米颗粒 |
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| 引用本文： | 包寒,罗静,时连鑫,徐福建,王树涛.采用超疏水微柱阵列模板法制备多糖凝胶微米颗粒[J].高等学校化学学报,2020,41(7):1484. |
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| 作者姓名： | 包寒 罗静 时连鑫 徐福建 王树涛 |
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| 作者单位： | 1.北京化工大学生物医用材料北京实验室, 北京 1000292.中国科学院理化技术研究所, 中国科学院仿生材料与界面科学重点实验室, 北京 100190 |
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| 基金项目： | 国家自然科学基金(21972155);国家高层次人才特殊支持计划 |
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| 摘 要： | 开发了一种制备尺寸均一的多糖基微凝胶(PsMH)的新方法: 以超疏水、 高黏附的微米级圆柱状结构硅基底为模板, 通过在微柱结构顶端黏附微液滴, 并在挥发过程中紫外固化, 制备了扁平状的PsMH. 研究发现, 采用此方法制备的PsMH尺寸均一, 且均匀分布在微柱顶端. 通过改变凝胶预聚液浓度及微柱直径, 可以有效调节PsMH的尺寸. 这种多糖基微凝胶有望应用于药物递送及纳米粒子载体等方面.
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| 关 键 词： | 多糖水凝胶 微米柱状阵列 微米级凝胶 超疏水阵列模板 |
| 收稿时间： | 2020-04-08 |
Fabricating Polysaccharide Micro-hydrogel via Superhydrophobic Pillar-structured Si Substrate † |
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| BAO Han,LUO Jing,SHI Lianxin,XU Fujian,WANG Shutao.Fabricating Polysaccharide Micro-hydrogel via Superhydrophobic Pillar-structured Si Substrate †[J].Chemical Research In Chinese Universities,2020,41(7):1484. |
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| Authors: | BAO Han LUO Jing SHI Lianxin XU Fujian WANG Shutao |
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| Institution: | 1. Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, China2. CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, China |
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| Abstract: | We have demonstrated a novel method for fabricating polysaccharide micro-hydrogel(PsMH) with uniform sizes. Microdroplets were adhered to micro-pillars and UV-cured during droplets evaporation to fabricate bread-like PsMH with uniform micrometer scale sizes via super-hydrophobic, high-adhesion micro-sized cylindrical structure silicon substrate. Results show that the PsMH with narrow size distributes uniformly on the top of the micro-pillars. The sizes and structure of PsMH can be effectively adjusted via polymer concentration and the diameter of micro-pillars. This polysaccharide-based microgel is expected to be used in drug delivery, nanoparticles carrier and other aspects. |
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| Keywords: | Polysaccharide hydrogel Micro-pillar Micro-hydrogel Super-hydrophobic pillar-structured substrate |
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