用共轭亚油酸构筑层状液晶的药物传递系统

在水相中用共轭亚油酸(CLA)及其钠盐(SCL)构筑层状液晶相,并考察了其药物缓释行为.借助偏光显微镜并辅以目测确定CLA/SCL/H2O三元相图中的层状液晶相区,然后用偏光显微镜、小角X射线散射仪和旋转流变仪获得层状液晶的偏光织构、相参数和流变参数等,证实其适用于药物传递系统(DDS).采用透析法研究了负载亲水性药物5-氟尿嘧啶或亲油性药物姜黄素的层状液晶的释药曲线,结果表明,该类层状液晶对2种药物均有良好的缓释能力.

Fabrication of Lamellar Liquid Crystals of Conjugated Linoleic Acid as Drug Delivery Systems

The lamellar liquid crystals in aqueous phase using conjugated linoleic acid(CLA)and its conjugate base sodium conjugated linoleate(SCL)were fabricated,and drug release behavior of the resulted lamellar liquid crystals was investigated.The lamellar liquid crystal phase in the CLA/SCL/H 2O ternary phase diagram was determined by means of polarizing microscopy assisted by visual inspection.The polarized texture,phase parameters and rheological parameters of the lamellar liquid crystals were obtained by polarizing microscope,small-angle X-ray scattering system and rotational rheometer,and the experimental results confirm that the lamellar liquid crystals are suitable for drug delivery system(DDS).The releasing curves of a hydrophilic drug 5-fluorouracil and a lipophilic drug curcumin were measured by dialysis experiments using the drug-{loaded}lamellar liquid crystals as DDS,and good sustained release abilities for both drugs were provided by the lamellar liquid crystals.