| 聚合物纳米药物载体的研究进展 |
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| 引用本文： | 赵宇,曹琬晴,刘阳. 聚合物纳米药物载体的研究进展[J]. 高等学校化学学报, 2020, 41(5): 909-923. DOI: 10.7503/cjcu20190646 |
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| 作者姓名： | 赵宇 曹琬晴 刘阳 |
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| 作者单位： | 1. 南开大学化学学院, 功能高分子材料教育部重点实验室;2. 化学国家级教学示范中心(南开大学), 天津 300071 |
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| 基金项目： | 国家重点研发计划“纳米科技”项目(2018YFA0209700) |
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| 摘 要： | 近年来,大量研究结果表明纳米技术可显著提高传统药物的疾病治疗效果,并在生物医学领域引起了广泛关注.迄今,多种聚合物纳米体系已被研发并用于药物的靶向递送.随着纳米技术的不断发展,各类生物微环境响应的功能基团也被应用于构筑新型药物载体,以提高患病部位的药物富集及减少药物的毒副作用.聚合物纳米药物载体在癌症治疗、代谢类疾病治疗及抗菌等方面展现出巨大潜力.本文系统评述了聚合物纳米药物载体的最新研究进展及在生物医药方面的应用.
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| 关 键 词： | 纳米技术 聚合物 纳米药物载体 靶向药物递送 药物控释 |
| 收稿时间： | 2019-12-10 |
Recent Advances in Polymeric Nano-sized Carrier Systems |
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| ZHAO Yu,CAO Wanqing,LIU Yang. Recent Advances in Polymeric Nano-sized Carrier Systems [J]. Chemical Research In Chinese Universities, 2020, 41(5): 909-923. DOI: 10.7503/cjcu20190646 |
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| Authors: | ZHAO Yu CAO Wanqing LIU Yang |
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| Affiliation: | 1. Key Laboratory of Functional Polymer Materials of Ministry of Education,College of Chemistry, Nankai University, Tianjin 300071, China;2. National Chemical Experimental Teaching Demonstration Center(Nankai University), Tianjin 300071, China |
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| Abstract: | In recent years, the nanotechnology has attracted a lot of attention in biomedicine owing to the great enhancement of therapeutic efficiency. A variety of polymeric nano-sized carrier systems have been deve-loped for targeted drug delivery and drug controlled release. In order to improve drug accumulation in the focal lesions and reduce the side effects, smart stimuli-responsive nano-sized carriers have emerged. Now, the polymeric nano-sized drug carriers have shown great potential for cancers, metabolic disorders and infectious diseases. This review focuses on the recent advances in polymeric nano-sized carriers and their applications in biomedicine. |
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| Keywords: | Nanotechnology Polymer Nano-sized carrier system Targeted drug delivery Drug controlled release |
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