基于动态共价键的自愈性水凝胶及其在医学领域的应用

自愈性水凝胶作为一种新型仿生智能材料受到了科研人员的广泛关注.近年来,人们利用动态共价键、超分子作用,发展了一系列自愈性水凝胶,并将其应用于药物控释、细胞三维培养、组织工程等生物医用领域.本文总结和评述了基于动态共价键的自愈性水凝胶及这些水凝胶作为药物载体的相关研究,并展望了基于动态化学的自愈性水凝胶的未来发展.

Preparation and Bio-medical Applications of Dynamic Chemistry Based Self-healing Hydrogels

Self-healing hydrogel is a new generation smart material that has drawn great attention among researchers from multiple cutting edge areas.Self-healing hydrogels are continuously enriching our knowledge in developing new materials and changing our lives.In the recent decades,thanks to numerous dedicated researchers,series of self-healing hydrogels have been explored through dynamic chemistry and supramolecular interactions,which have been applied in interdisciplinary areas for controlled release of drugs,3 D cell culture,and scaffolds of tissue engineering,etc.Self-healing hydrogels can be injected as solid gels instead of liquid precursor,then selfheal in situ.Thus,self-healing hydrogels have been utilized as a new type of injectable carrier to deliver drugs.This method effectively avoids unwanted cargo loss throughout the cycling and dramatically improves the delivery efficiency of drugs.Thus,self-healing hydrogels have been studied in recent research as great therapeutic carrier for tumour therapy and wound-healing.This review aims to summarize some recent research progresses in the preparation of self-healing hydrogels based on different dynamic covalent bonds.The bio-medical applications of self-healing hydrogels including tumour therapy and wound-healing have also been introduced.The future development and challenges of dynamic chemistry based on self-healing hydrogels have also been discussed.