| Synthesis and Antitumor Activity of an Analog of Phthalascidin |
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| 引用本文： | Ye WANG Yan Li ZHOU Zhan Zhu LIU Shi Zhi CHEN Xiao Guang CHEN. Synthesis and Antitumor Activity of an Analog of Phthalascidin[J]. 中国化学快报, 2006, 17(10): 1279-1282 |
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| 作者姓名： | Ye WANG Yan Li ZHOU Zhan Zhu LIU Shi Zhi CHEN Xiao Guang CHEN |
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| 作者单位： | Institute of Materia Medica, Chinese Academy of Medical Sciences ＆ Peking Union Medical College, Beijing 100050 |
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| 基金项目： | 国家自然科学基金;北京市自然科学基金 |
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| 摘 要： | Ecteinascidin 743 (Et-743) is an exceedingly potent antitumor agent isolated from the extracts of the marine tunicate Ecteinascidia turbinate1 that is currently undergoing phase Ⅱ/Ⅲ clinical trials in Europe and the United States2. As the result of its …
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| 关 键 词： | 四氢异喹啉 抗癌抗菌素 Ecteinascidin phthalascidin 合成 |
| 收稿时间： | 2006-04-19 |
Synthesis and Antitumor Activity of an Analog of Phthalascidin |
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| Ye WANG,Yan Li ZHOU,Zhan Zhu LIU,Shi Zhi CHEN,Xiao Guang CHEN. Synthesis and Antitumor Activity of an Analog of Phthalascidin[J]. Chinese Chemical Letters, 2006, 17(10): 1279-1282 |
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| Authors: | Ye WANG Yan Li ZHOU Zhan Zhu LIU Shi Zhi CHEN Xiao Guang CHEN |
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| Abstract: | An analog of phthalascidin (Pt-650) was synthesized with an improved synthetic route. With precursor 2 as the starting material, compound 1 was prepared through 4 steps in a total yield of 47%. In vitro antitumor test of this Pt-650 analog showed that it possessed strong toxicity against a number of tumor cell lines including A2780, A549, Bel-7402, BGC-823, HELA, KB, KeTr3 and HCT-8. |
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| Keywords: | Ecteinascidin phthalascidin tetrahydroisoquinoline antitumor. |
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