Fast capillary GC using a low thermal mass column oven for the determination of residual solvents in pharmaceuticals |
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Authors: | David Frank Szücs Roman Makwana Jay Sandra Pat |
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Institution: | Pfizer Analytical Research Centre, Ghent University, Krijgslaan, Ghent, Belgium. |
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Abstract: | A low thermal mass column oven was used for fast capillary GC analysis (high throughput) of residual solvents in pharmaceutical products. A dedicated capillary column, 20 m L x 180 microm ID x 1 microm DB-624 was programmed from 35 degrees C (30 s) to 150 degrees C at 100 degrees C/min and to 250 degrees C (30 s) at 200 degrees C/min, resulting in a total GC cycle time of less than 4 min. Complete separation of a target 20-component mixture was achieved, while method performance in terms of repeatability, sensitivity, and linearity was maintained in comparison to the generic method currently applied in our laboratories. |
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Keywords: | Capillary gas chromatography High throughput Low thermal mass column oven Pharmaceutical analysis Residual solvents |
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