Catalytic asymmetric addition of alcohols to imines: enantioselective preparation of chiral N,O-aminals |
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Authors: | Li Guilong Fronczek Frank R Antilla Jon C |
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Affiliation: | Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205A, Tampa, Florida 33620, USA. |
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Abstract: | The enantioselective addition of alcohols to imine electrophiles has been shown to proceed in the presence of a catalytic amount of a chiral phosphoric acid catalyst. The reaction allows for the formation of the respective chiral N,O-aminals in excellent yield and enantioselectivity. A total of 11 different alcohols and 11 different imines were successfully used as a clear demonstration of the reaction generality. |
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