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Microwave-assisted parallel synthesis of a 4,6-diamino-2,2-dimethyl-1,2-dihydro-1-phenyl-s-triazine library
Authors:Lee Hong-Kee  Rana Tariq M
Affiliation:Program in Chemical Biology, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.
Abstract:Microwave-assisted parallel synthesis of a library of 20 phenyl dihydrotriazines was successfully achieved and compared to an identical library generated by conventional parallel synthesis. Microwave synthesis dramatically decreased reaction times from an average of 22 h to 35 min, and compounds generated using microwave irradiation were purer. Isolated yields of all the compounds were comparable when the two methods were used.
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