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Facile synthesis of 6-organyl-4-(trifluoromethyl)pyridin-2(1H)-ones and their polyfluoroalkyl-containing analogs |
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| Authors: | Kushch S O Goryaeva M V Burgart Ya V Triandafilova G A Malysheva K O Krasnykh O P Gerasimova N A Evstigneeva N P Saloutin V I |
| Institution: | 1.I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, 22/20 ul. S. Kovalevskoi, 620108, Yekaterinburg, Russian Federation ;2.Perm National Research Polytechnic University, 29 Komsomolskii prosp., 614990, Perm, Russian Federation ;3.Ural Research Institute of Dermatovenereology and Immunopathology, 8 ul. Shcherbakova, 620076, Yekaterinburg, Russian Federation ; |
| Abstract: | The three-component cyclization of 3-polyfluoroalkyl-3-oxopropanoates and methyl ketones with ammonium acetate affords 6-organyl-4-(polyfluoroalkyl)pyridin-2(1H)-ones (organyl is alkyl, aryl, or hetaryl). The synthesized pyridones were evaluated for antifungal, antibacterial, and analgesic activity. |
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