Synthesis and antioxidant properties of N-substituted aminomethyl derivatives of 2-isobornylphenol

A series of 2-isobornylphenol derivatives containing aminomethyl groups either at ortho-(monoderivatives) or ortho- and para-positions (bis-derivatives) relative to the hydroxy group of phenol moiety was synthesized. Antioxidant properties of the obtained compounds were comparatively evaluated using in vitro models. It was demonstrated that Mannich bases containing an n-octylaminomethyl group are significantly exceeding both starting 2-isobornylphenol and the standard antioxidant, 2,6-di-tert-butyl-4-methylphenol, by their ability to inhibit H₂O₂-induced erythrocyte hemolysis.