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New membranotropic cationic chlorins derived from pheophytin a: synthesis and evaluation of photodynamic activity |
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| Authors: | Khudyaeva I. S. Shevchenko O. G. Belykh D. V. |
| Affiliation: | 1.Institute of Chemistry, Komi Science Center, Ural Branch of the Russian Academy of Sciences, 48 ul. Pervomaiskaya, 167982, Syktyvkar, Russian Federation ;2.Institute of Biology, Komi Science Centre, Ural Branch of the Russian Academy of Sciences, 28 ul. Kommunisticheskaya, 167982, Syktyvkar, Russian Federation ; |
| Abstract: | A series of new chlorins bearing the phytyl moiety and different number of cationic groups were synthesized based on pheophytin a. A comparative evaluation of dark cytotoxicity and photodynamic activity of the synthesized compounds was performed using mature mammalian erythrocytes. Both dark and photoinduced hemolytic activities of the synthesized compounds grow with increasing the number of the cationic group in the molecule. |
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