Indole diterpene synthetic studies: development of a second-generation synthetic strategy for (+)-nodulisporic acids A and B |
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| Authors: | Smith Amos B Kürti László Davulcu Akin H Cho Young Shin Ohmoto Kazuyuki |
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| Affiliation: | Department of Chemistry, Monell Chemical Senses Center and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu |
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| Abstract: | A second-generation strategy for construction of (+)-nodulisporic acids A and B based on the development of a new, effective modular indole synthesis exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic is disclosed. This strategy evolved due to the considerable acid instability of the C(24) hydroxyl group observed in several advanced intermediates during our first-generation approach. |
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