NMR elucidation of novel ligands derived from (R)-(+)-camphor |
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Authors: | Grant A Boyle Thavendran Govender Hendrik G Kruger Glenn E M Maguire |
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Institution: | (1) School of Chemistry, University of KwaZulu-Natal, Durban, 4041, South Africa;(2) School of Pharmacy and Pharmacology, University of KwaZulu-Natal, Durban, 4041, South Africa |
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Abstract: | The complete NMR elucidation of five camphor-derived ligands is reported. 2D NMR techniques such as NOESY are used to assist
in the determination of the orientation of the donor groups in space. The compounds were synthesized as ligands to be used
in asymmetric catalysis. They represent the first instance where both donor groups are pendant on the C3 position of the camphor
skeleton. The single crystal X-ray structure of one of the ligands was obtained and was helpful in determining the potential
NOESY interactions within the molecule. For the other ligands, density functional theory (DFT) optimizations was performed
B3LYP/6-31+g(d)] to visualize possible NOE interactions.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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Keywords: | Chiral Camphor 2D NMR X-ray |
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