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| 无种子法纳米金棒的制备及其对肿瘤细胞光热治疗效应研究 | |
| 引用本文： | 王新环,韩秋森,李婧影,杨蓉,刁国旺,王琛. 无种子法纳米金棒的制备及其对肿瘤细胞光热治疗效应研究[J]. 物理化学学报, 2001, 30(7): 1363-1369. DOI: 10.3866/PKU.WHXB201405063 |
| 作者姓名： | 王新环 韩秋森 李婧影 杨蓉 刁国旺 王琛 |
| 作者单位： | 1. 扬州大学化学化工学院, 江苏扬州 225002; 2. 国家纳米科学中心, 纳米生物效应与安全性重点实验室, 北京 100190 |
| 基金项目： | 国家自然科学基金（21261130090，21073047）和中国科学院先导科技专项（XDA09030303）资助项目 |
| 摘 要： | 采用简便快捷的无种子法一步完成了纳米金棒的制备. 通过改变实验条件可以调控纳米金棒的吸收峰从可见到近红外转移. 将巯基聚乙二醇（PEG-SH）置换金棒表面的十六烷基三甲基溴化铵（CTAB）分子，大大提高了金棒的生物相容性. 制备的纳米金棒在近红外（NIR）光照射下对肿瘤细胞有很好的杀伤效果.研究结果为纳米金棒用于抗肿瘤治疗提供了实验基础. |
| 关 键 词： | 纳米金棒 等离子共振吸收 生物相容性 表面修饰 热疗 |
| 收稿时间： | 2014-03-17 |
| 修稿时间： | 2014-05-06 |
Seedless Synthesis of Gold Nanorods and Applications in Photo-Thermal Cancer Therapy |
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| WANG Xin-Huan,HAN Qiu-Sen,LI Jing-Ying,YANG Rong,DIAO Guo-Wang,WANG Chen. Seedless Synthesis of Gold Nanorods and Applications in Photo-Thermal Cancer Therapy[J]. Acta Physico-Chimica Sinica, 2001, 30(7): 1363-1369. DOI: 10.3866/PKU.WHXB201405063 | |
| Authors: | WANG Xin-Huan HAN Qiu-Sen LI Jing-Ying YANG Rong DIAO Guo-Wang WANG Chen |
| Affiliation: | 1. College of Chemistry and Chemical Engineering, University of Yangzhou, Yangzhou 225002, Jiangsu Province, P. R. China; 2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, P. R. China |
| Abstract: | We report the synthesis of gold nanorods with a simple and efficient seedless method. By changing the experimental conditions, the longitudinal absorption peak of the gold nanorods can be shifted from the visible to the near-infrared region. Mercaptopolyethylene glycol (PEG-SH) was then used to substitute cetyltrimethyl ammoniumbromide (CTAB) to improve the biocompatibility of the gold nanorods. A strong inhibition of cancer cell growth was observed with the modified gold nanorods under near-infrared (NIR) light irradiation. Our results will be helpful for the potential applications of gold nanorods in clinical photo-thermal cancer therapy. |
| Keywords: | Gold nanorod Plasmon resonance absorption Biocompatibility Surface functionalization Hyperthermia |
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