The absolute stereochemistry of grenadamide |
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| Authors: | Juma'a R. Al Dulayymi Keith Jones |
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| Affiliation: | Department of Chemistry, University of Wales, Bangor, Gwynedd Wales LL57 2UW, UK |
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| Abstract: | 3-(2S-Heptylcycloprop-1S-yl)propanoic acid 2-phenylethanamide was synthesised from cis-cyclopropan-1,2-dimethanol via enzymatic desymmetrisation of the dibutyrate; it gave identical NMR spectroscopic data to those reported for grenadamide but had an equal and opposite absolute rotation, indicating that the latter is the 2R,1R-enantiomer. |
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| Keywords: | Grenadamide Stereochemistry Synthesis |
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