Bia-amperometric quantification of salbutamol in pharmaceutical products |
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Authors: | Quintino Maria S M Angnes Lúcio |
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Institution: | Departamento de Quimica Fundamental, Instituto de Quimica, Universidade de S?o Paulo, Av. Prof. Lineu Prestes, 748-05508-900 S?o Paulo, SP, Brazil. |
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Abstract: | This paper presents a simple, rapid and reproducible method of analysis of salbutamol in pharmaceutical products, utilizing batch injection analysis (BIA) associated with amperometric detection. A study of salbutamol oxidation demonstrated a strong dependence between electrode fouling and pH. All determinations were done utilizing a glassy carbon electrode in presence of 3.0 mol l−1 NaOH. A large linear dynamic range from 8×10−7 to 2×10−4 mol l−1 was obtained by using an injected volume of 100 μl with a detection limit of 2.5×10−7 mol l−1. R.S.D. of 0.92% for 50 successive injections of 4×10−6 mol l−1 of salbutamol and a sample throughput of 60 samples per hour were achieved. The method was applied for salbutamol quantification in syrups. |
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Keywords: | Salbutamol BIA Amperometry Pharmaceutical products |
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