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Potassium permanganate-glyoxal chemiluminescence system for flow injection analysis of cephalosporin antibiotics: cefalexin, cefadroxil, and cefazolin sodium in pharmaceutical preparations
Authors:Sun Yuanyuan  Tang Yuhai  Yao Hong  Zheng Xiaohui
Affiliation:Department of Chemistry, College of Science, Xi’an Jiaotong University, Xi’an 710061, PR China
Abstract:A sensitive flow injection chemiluminescence (FL-CL) method for the determination of cephalosporin antibiotics, was developed. The method was based on that cephalosporin antibiotics could enhance the CL reaction of glyoxal and KMnO4 in sulfuric acid. Method development included the optimization of reagent concentrations and flow-rate. Under the optimized conditions, three cephalosporin antibiotics: cefalexin, cefadroxil, and cefazolin sodium, were determined. The detection limits of the method are 10 ng ml−1 cefalexin, 2 ng ml−1 cefadroxil, and 2 ng ml−1 cefazolin sodium. The method was successfully applied to the determination of three cephalosporin antibiotics in pharmaceutical preparations.
Keywords:Chemiluminescence   Flow injection   Cephalosporins   Pharmaceutical preparations
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