Use of hydrolases for the synthesis of cyclic amino acids |
| |
Authors: | Richard C Lloyd Karen E Holt Jonathan P Swift Philip A Keene Stephen J.C Taylor Raymond McCague |
| |
Affiliation: | Dowpharma, Chirotech Technology Ltd, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK |
| |
Abstract: | The synthesis of several cyclic amino acids that have all the necessary structural features to make them ideal scaffolds for use in medicinal chemistry is described. A key step in each synthesis is the use of hydrolase enzymes to define a chiral centre. In order to elaborate these building blocks into more complex molecules, crystallization and asymmetric hydrogenation were used to define further stereocentres. |
| |
Keywords: | Biocatalysis Amino acids Stereochemistry |
本文献已被 ScienceDirect 等数据库收录! |