Zr-promoted ‘pair’-selective and regioselective synthesis of penta-substituted benzene derivatives |
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Authors: | Yves R Dumond |
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Institution: | Herbert C. Brown Laboratories of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907-2084, USA |
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Abstract: | Tetra-substituted zirconacyclopentadiene derivatives, obtainable via in situ generation of zirconacyclopropenes and their cyclic carbozirconation with alkynes, can be treated with alkynyllithiums to induce 1,2-migration accompanied by aromatization and protonolysis, leading to the formation of penta-substituted benzene derivatives, in which all five substituted may be different. |
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Keywords: | Zr-Promoted &lsquo Pair&rsquo -and regioselective synthesis Penta-substituted benzenes Zirconacyclopentadienes Alkynylzirconate migratory insertion |
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