Synthesis, crystal structures and in vitro antitumor activities of some organoantimony arylhydroxamates |
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| Authors: | Guo-Cang Wang Jian Xiao Hai-Bin Song Jing-Rong Cui Fu-Xiang Ran |
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| Affiliation: | a School of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
b National Research Laboratories of Natural and Biomimetic Drugs, Peking University, Beijing 100083, China |
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| Abstract: | A series of novel organoantimony arylhydroxamates with the formulae [Ar3SbL2]−[HNEt3]+ (LH = arylhydroxamic acid; Ar = C6H5, 4-CH3C6H4, 3-CH3C6H4, 4-ClC6H4, 4-FC6H4) and (4-CH3C6H4)4SbL were synthesized and characterized by elemental analysis, IR, 1H NMR and mass spectroscopy. The crystal structures of (4-CH3C6H4)4SbL and [Ph3SbL2]−[HNEt3]+ were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against three human cancer cells are reported. |
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| Keywords: | Organoantimony Arylhydroxamic acid Crystal structures Antitumor activity |
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