Reactions of 1-alkynylphosphonates with group (IV) complexes |
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Authors: | Abed Al-Aziz Al-Quntar |
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Affiliation: | Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Hebrew University in Jerusalem, P.O. Box 12065, Jerusalem 91120, Israel |
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Abstract: | This article describes our recent methods for the synthesis of substituted vinylphosphonates by reacting 1-alkynylphosphnates with group (IV) complexes. cis-Vinylphosphonates, 1,3-butadienylphosphonates, 1-(hydroxymethyl)vinylphosphonates, 2-(hydroxymethyl)vinylphosphonates, (E) 3-oxo-1-alkenylphosphonates were produced as a result of the reactions between zirconium complexes and 1-alkynylphosphonates. On the other hand, titanium complexes afford 3-aminovinylphoshonates, 1,4-bis-phosphonates, and various other di- and tri-substituted vinylphosphonates. An evaluation of access of these recently synthesized vinylphosphonates as MMP-2 inhibitors has shown that certain compounds are very potent and promising. |
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Keywords: | Vinylphosphonates Gr(IV) complexes |
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