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A pH‐Responsive MRI Agent that Can Be Activated Beyond the Tissue Magnetization Transfer Window |
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| Authors: | Xiaojing Wang Dr Yunkou Wu Dr Todd C Soesbe Dr Jing Yu Dr Piyu Zhao Dr Garry E Kiefer Prof A Dean Sherry |
| Institution: | 1. Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080 (USA);2. Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 (USA);3. Macrocyclics, 1309 Record Crossing, Dallas, TX 75235 (USA) |
| Abstract: | A terbium‐based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56 ppm in a bound water molecule exchange peak between pH 5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal. |
| Keywords: | imaging agents lanthanides magnetic resonance imaging magnetization transfer paraCEST |