Iridium‐Catalyzed Enantioselective Allylic Alkylation with Functionalized Organozinc Bromides |
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| Authors: | James Y Hamilton Dr David Sarlah Prof?Dr Erick M Carreira |
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| Institution: | Eidgen?ssische Technische Hochschule Zürich, HCI H335, Vladimir‐Prelog‐Weg 3, 8093 Zürich (Switzerland) http://www.carreira.ethz.ch |
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| Abstract: | Iridium‐catalyzed enantioselective allylic alkylation of branched racemic carbonates with functionalized alkylzinc bromide reagents is described. Enabled by a chiral Ir/(P,olefin) complex, the method described allows allylic substitution with various primary and secondary alkyl nucleophiles with excellent regio‐ and enantioselectivities. The developed reaction was showcased in a concise, asymmetric synthesis of (?)‐preclamol. |
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| Keywords: | alkylation allylic compounds enantioselectivity iridium zinc |
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