|
|||||
|
|
Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters |
|
| Authors: | Jin‐Sheng Yu Fu‐Min Liao Wei‐Ming Gao Kui Liao Run‐Lin Zuo Prof. Dr. Jian Zhou |
| Affiliation: | 1. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N, Zhongshan Road, Shanghai 200062 (China);2. No 15 class of Grade 2012, Luzhou High School, 33 Zhongshan Road, Luzhou 646000 (China);3. State Key Laboratory of Elemento‐organic Chemistry, Nankai University, Tianjin 300071 (P.R. China) |
| Abstract: | A chiral secondary amine phosphoramide was developed and identified as a powerful catalyst for the Mukaiyama–Michael addition of fluorinated enol silyl ethers to tetrasubstituted olefins. The resulting products are obtained with high enantioselectivities and contain a quaternary carbon stereocenter bearing either a difluoroalkyl or monofluoroalkyl group. |
| Keywords: | amines asymmetric catalysis chirality fluorine organocatalysis |