Gold‐Catalyzed Cyclization Leads to a Bridged Tetracyclic Indolenine that Represses β‐Lactam Resistance |
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| Authors: | Dr. Wenqing Xu Dr. Wei Wang Prof. Dr. Xiang Wang |
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| Affiliation: | Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 (USA) |
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| Abstract: | A gold‐catalyzed desilylative cyclization was developed for facile synthesis of bridged tetracyclic indolenines, a common motif in many natural indole alkaloids. An antimicrobial screen of the cyclization products identified one compound which selectively potentiates β‐lactam antibiotics in methicillin‐resistant S. aureus (MRSA), and re‐sensitizes a variety of MRSA strains to β‐lactams. |
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| Keywords: | antibiotics drug discovery gold heterocycles synthetic methods |
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