In Vivo Endoscopic Tissue Identification by Rapid Evaporative Ionization Mass Spectrometry (REIMS) |
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| Authors: | Dr Julia Balog Dr Sacheen Kumar James Alexander Ottmar Golf Dr Juzheng Huang Tom Wiggins Nima Abbassi‐Ghadi Dr Attila Enyedi Dr Sandor Kacska James Kinross Prof George B Hanna Prof Jeremy K Nicholson Prof Zoltan Takats |
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| Institution: | 1. Computational and Systems Medicine, Imperial College London, South Kensington Campus, London SW7 2AZ (UK);2. Department of Surgery and Cancer, Imperial College London, St. Mary's Hospital, QEQM 10th floor, London W2 1NY (UK);3. Institute of Surgery, University of Debrecen, Moricz Zsigmond krt. 22, Debrecen 4032 (Hungary);4. Gastroenterology Clinic, University of Debrecen, Nagyerdei krt. 98., Debrecen 4032 (Hungary) |
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| Abstract: | Gastrointestinal cancers are a leading cause of mortality, accounting for 23 % of cancer‐related deaths worldwide. In order to improve outcomes from these cancers, novel tissue characterization methods are needed to facilitate accurate diagnosis. Rapid evaporative ionization mass spectrometry (REIMS) is a technique developed for the in vivo classification of human tissue through mass spectrometric analysis of aerosols released during electrosurgical dissection. This ionization technique was further developed by utilizing surface induced dissociation and was integrated with an endoscopic polypectomy snare to allow in vivo analysis of the gastrointestinal tract. We tested the classification performance of this novel endoscopic REIMS method in vivo. It was shown to be capable of differentiating between healthy layers of the intestinal wall, cancer, and adenomatous polyps based on the REIMS fingerprint of each tissue type in vivo. |
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| Keywords: | cancer endoscopy in vivo characterization mass spectrometry phospholipids |
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