Nickel‐Catalyzed Chemo‐, Regio‐ and Diastereoselective Bond Formation through Proximal CC Cleavage of Benzocyclobutenones |
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| Authors: | Dr. Francisco Juliá‐Hernández Dr. Asraa Ziadi Dr. Akira Nishimura Prof. Ruben Martin |
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| Affiliation: | 1. Institute of Chemical Research of Catalonia (ICIQ), Av. Pa?sos Catalans 16, 43007 Tarragona (Spain);2. Catalan Institution for Research and Advanced Studies (ICREA), Passeig Llu?s Companys, 23, 08010 Barcelona (Spain) |
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| Abstract: | The first catalytic intermolecular proximal C1? C2 cleavage of benzocyclobutenones (BCB) without prior carbonyl activation or employing noble metals has been developed. This protocol operates at room temperature and is characterized by an exquisite chemo‐, regio‐ and diastereoselectivity profile, constituting a unique platform for preparing an array of elusive carbocyclic skeletons. |
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| Keywords: | benzocyclobutenones C C activation nickel catalysis ring strain |
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