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Catalytic Enantioselective Reaction of α‐Aminoacetonitriles Using Chiral Bis(imidazoline) Palladium Catalysts |
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| Authors: | Masaru Kondo Tomoki Nishi Prof Dr Tsubasa Hatanaka Prof Dr Yasuhiro Funahashi Prof Dr Shuichi Nakamura |
| Institution: | 1. Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa‐ku, Nagoya 466‐8555 (Japan) http://www.ach.nitech.ac.jp/～organic/nakamura/index.html;2. Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560‐0043 (Japan) |
| Abstract: | The catalytic enantioselective reaction of diphenylmethylidene‐protected α‐aminoacetonitriles with imines has been developed. Good yields and diastereo‐ and enantioselectivities were observed for the reaction of various imines using chiral bis(imidazoline)/Pd catalysts. The reaction of α‐aminonitriles with di‐tert‐butyl azodicarboxylate afforded chiral α,α‐diaminonitriles in high yields with high enantioselectivities. |
| Keywords: | asymmetric catalysis diastereoselectivity palladium silver synthetic methods |