Reliable Quantitative SERS Analysis Facilitated by Core–Shell Nanoparticles with Embedded Internal Standards |
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| Authors: | Wei Shen Xuan Lin Prof Chaoyang Jiang Chaoyu Li Haixin Lin Jingtao Huang Shuo Wang Dr Guokun Liu Prof Xiaomei Yan Prof Qiling Zhong Prof Bin Ren |
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| Institution: | 1. State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), MOE laboratory of Spectrochemical Analysis and Instrumentation, The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 (China) http://bren.xmu.edu.cn;2. College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022 (China);3. Department of Chemistry, The University of South Dakota, 414 E. Clark St., Vermillion, SD 57069 (USA) |
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| Abstract: | Quantitative analysis is a great challenge in surface‐enhanced Raman scattering (SERS). Core‐molecule‐shell nanoparticles with two components in the molecular layer, a framework molecule to form the shell, and a probe molecule as a Raman internal standard, were rationally designed for quantitative SERS analysis. The signal of the embedded Raman probe provides effective feedback to correct the fluctuation of samples and measuring conditions. Meanwhile, target molecules with different affinities can be adsorbed onto the shell. The quantitative analysis of target molecules over a large concentration range has been demonstrated with a linear response of the relative SERS intensity versus the surface coverage, which has not been achieved by conventional SERS methods. |
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| Keywords: | analytical methods internal standards nanoparticles quantitative analysis Raman spectroscopy |
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