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Toward Naphthocyclinones: Doubly Connected Octaketide Dimers with a Bicyclo[3.2.1]octadienone Core by Thiolate‐Mediated Cyclization |
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| Authors: | Dr Yoshio Ando Subaru Hori Takumi Fukazawa Prof?Dr Ken Ohmori Prof?Dr Keisuke Suzuki |
| Institution: | Department of Chemistry, Tokyo Institute of Technology, 2‐12‐1 O‐okayama, Meguro, Tokyo 152‐8551 (Japan) |
| Abstract: | A viable method is reported for the synthesis of the bicyclo3.2.1]octadienone scaffold in naturally occurring octaketide dimers. The procedure employs a reductive cyclization reaction mediated by an unusual ethanedithiol monosodium salt. |
| Keywords: | cyclization dimerization dithiol reagents quinones synthetic methods |