Gold‐Catalyzed Cascade Cyclization of 2‐Alkynyl‐N‐Propargylanilines by Rearrangement of a Propargyl Group |
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| Authors: | Yusuke Tokimizu Dr Shinya Oishi Prof Dr Nobutaka Fujii Prof Dr Hiroaki Ohno |
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| Institution: | Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo‐ku, Kyoto 606‐8501 (Japan) |
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| Abstract: | Gold catalysis enables direct construction of tetracyclic fused indolines through the migration of a propargyl substituent from an aniline nitrogen atom to the C3‐position of an indole from 2‐alkynyl‐N‐propargylanilines. This reaction provides rapid access to fused three‐dimensional indolines in a single operation with the formation of four bonds and three rings. |
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| Keywords: | allenes gold homogeneous catalysis indolines rearrangement |
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