Pd‐Catalyzed Regioselective Activation of gem‐Difluorinated Cyclopropanes: A Highly Efficient Approach to 2‐Fluorinated Allylic Scaffolds |
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| Authors: | Jun Xu Ebrahim‐Alkhalil Ahmed Bin Xiao Qian‐Qian Lu Yun‐Long Wang Chu‐Guo Yu Prof Yao Fu |
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| Institution: | 1. iChEM, CAS Key Laboratory of Urban Pollutant Conversion, Department of Chemistry, University of Science and Technology of China, Hefei 230026 (China);2. School of Medical Engineering, Hefei University of Technology, Hefei 230009 (China) |
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| Abstract: | An unprecedented Pd‐catalyzed regioselective activation of gem‐difluorinated cyclopropanes induced by C? C bond cleavage is reported. It provides a general and efficient access to a variety of 2‐fluoroallylic amines, ethers, esters, and alkylation products in high Z‐selectivity, which are important skeletons in many biologically active molecules. In addition, the transformation represents the first general application of gem‐difluorinated cyclopropanes as reaction partners in transition‐metal‐catalyzed cross‐coupling reaction. |
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| Keywords: | C(sp3) F activation C C bond cleavage fluorinated compounds gem‐difluorinated cyclopropanes palladium |
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