Ligand‐Free Copper‐Catalyzed Negishi Coupling of Alkyl‐, Aryl‐, and Alkynylzinc Reagents with Heteroaryl Iodides |
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| Authors: | Surendra Thapa Arjun Kafle Dr. Santosh K. Gurung Adam Montoya Patrick Riedel Prof. Ramesh Giri |
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| Affiliation: | Department of Chemistry & Chemical Biology, The University of New Mexico, Albuquerque, NM 87131 (USA) |
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| Abstract: | Reported herein is an unprecedented ligand‐free copper‐catalyzed cross‐coupling of alkyl‐, aryl‐, and alkynylzinc reagents with heteroaryl iodides. The reaction proceeds at room temperature for the coupling of primary, secondary, and tertiary alkylzinc reagents with heteroaryl iodides without rearrangement. An elevated temperature (100 °C) is required for aryl–heteroaryl and alkynyl–heteroaryl couplings. |
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| Keywords: | copper cross‐coupling heterocycles synthetic methods zinc |
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