药物小分子穿越磷脂双层膜输运过程中的时滞效应

本文基于扩散动力学，建立了一种新的药物小分子穿越磷脂双层膜输运的理论模型，研究药物小分子穿越磷脂双层膜输运的动态过程，考察药物小分子跨膜输运过程中的时间延迟(时滞)效应。研究发现，药物小分子在数分钟内穿越磷脂双层膜各区域进入细胞，由于时滞效应，穿膜过程呈现了周期性演化特性。当药物小分子数量增加到一定程度，磷脂分子层会出现微小孔，让积累的药物小分子快速通过。通过分析模型中各参数的敏感性，我们还发现，药物小分子在磷脂双层膜内不同区域的扩散特性，以及输运过程的时滞性，都会对药物小分子穿越磷脂双层膜的动力学有较大程度的影响。理论结果符合模拟、实验观测，进一步深刻揭示了药物小分子穿越磷脂双层膜的穿膜特性，可为设计确切的疗法药物提供必要的参考和新方案。

Time-delay effect of small drug molecules transporting across phospholipid bilayer membrane

In this paper, based on the diffusion kinetics, a new theoretical model for the transport of small drug molecules across the phospholipid bilayer membrane is established. We analyze the dynamic process of the transport of small drug molecules across the phospholipid bilayer membrane. Especially, time delay effects in the transmembrane transport process of drug molecules are investigated. We found that the small drug molecules crossed the various regions of the phospholipid bilayer membrane and entered the cell within a few minutes. When the number of small drug molecules increases to a certain level, tiny pores will appear in the phospholipid molecule layer, allowing the accumulated drug molecules to pass through quickly. By analyzing the sensitivity of each parameter in the model, we also found that the diffusion characteristics of drug molecules in different regions of the phospholipid bilayer membrane and the time delay of the transport process will affect the kinetics of small drug molecules crossing the phospholipid bilayer membrane. Our theoretical results are consistent with simulation and experimental observations. It further revealing the transmembrane properties of small drug molecules across phospholipid bilayer membranes, which can provide necessary references and new solutions for the design of exact therapeutic drugs.