Highly efficient synthesis of a class of novel chiral-bridged atropisomeric monophosphine ligands via simple desymmetrization and their applications in asymmetric Suzuki-Miyaura coupling reaction |
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| Authors: | Wang Shouliang Li Jinjin Miao Tingting Wu Wenhao Li Qing Zhuang Yue Zhou Zhongyuan Qiu Liqin |
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| Affiliation: | School of Chemistry and Chemical Engineering, Guangdong Engineering Research Center of Chiral Drugs, Sun Yat-Sen University, No. 135 Xingangxi Road, Guangzhou 510275, PR China. |
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| Abstract: | A series of novel chiral-bridged atropisomeric monophosphine ligands were synthesized via convenient and simple pathways. The prepared ligands, especially for ligand 7d, were found to be highly effective in the Pd-catalyzed Suzuki-Miyaura coupling reaction. The steric hindrance and electronic effect of substrates on the reactivity and enantioselectivity were explored preliminarily. |
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