| Interaction Between HMG Proteins (1+2) and the Negative Regulatory Region 1(NCR1) in the 5''''-flanking Sequence of the Human β-globin Gene |
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| 作者姓名： | 钱若兰 陈雅娣 胡玉龙 李民乾 王中怀 徐耀良 |
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| 作者单位： | Shanghai Institute of Cell Biology，Academia Sinica，Shanghai 200031，PRC，Shanghai Institute of Cell Biology，Academia Sinica，Shanghai 200031，PRC，Shanghai Institute of Cell Biology，Academia Sinica，Shanghai 200031，PRC，Shanghai Institute of Nuclear Research，Academia Sinica，Shanghai 201800，PRC，Shanghai Institute of Nuclear Research，Academia Sinica，Shanghai 201800，PRC，Shanghai Institute of Nuclear Research，Academia Sinica，Shanghai 201800，PRC |
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| 基金项目： | This work was supported by grants from Academia Sinica. |
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| 摘 要： | The pattern of high mobility group proteins 1 and 2 (HMG1,2) interaction with the 5'-flanking sequence of the human β-globin gene has been analyzed by scanning tunnelling microscopy (STM). A 200 bp negative regulatory region in the 5'-flanking sequence of the human β-globin gene can be folded by HMG proteins 1 and 2 into a circular structure (diameter 70±6) with a linear tail which seems to be a left-handed double helix structure.
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| 关 键 词： | HMG protein STM β-globin gene chromatin folding |
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