In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues |
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| Authors: | Matthes Diana Richter Lennart Müller Jane Denisiuk Alexander Feifel Sven C Xu Yuquan Espinosa-Artiles Patricia Süssmuth Roderich D Molnár István |
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| Affiliation: | Technische Universit?t Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany. |
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| Abstract: | New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene. |
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