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Direct guanidinylation of aryl and heteroaryl halides via copper-catalyzed cross-coupling reaction |
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| Authors: | Hammoud Hassan Schmitt Martine Bihel Frédéric Antheaume Cyril Bourguignon Jean-Jacques |
| Affiliation: | Laboratoire d'Innovation Thérapeutique, UMR 7200, Faculté de pharmacie, Université de Strasbourg, 74 route du Rhin, BP 60024, 67401 Illkirch, France. |
| Abstract: | A modified Ullmann reaction using p-methoxybenzyl (PMB) guanidine as guanidinylation agent yielded various aryl and heteroaryl guanidines in good yields. |
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