Three-component coupling sequence for the regiospecific synthesis of substituted pyridines |
| |
Authors: | Chen Ming Z Micalizio Glenn C |
| |
Institution: | Kellogg School of Science and Technology at The Scripps Research Institute, The Scripps Research Institute, Scripps Florida, Jupiter, Florida 33458, USA. |
| |
Abstract: | A de novo synthesis of substituted pyridines is described that proceeds through nucleophilic addition of a dithiane anion to an α,β-unsaturated carbonyl followed by metallacycle-mediated union of the resulting allylic alcohol with preformed trimethylsilane-imines (generated in situ by the low-temperature reaction of lithium hexamethyldisilazide with an aldehyde) and Ag(I)- or Hg(II)-mediated ring closure. The process is useful for the convergent assembly of di- through penta-substituted pyridines with complete regiochemical control. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|